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Abstract
This document features an exploration of the hormesis effect induced by intermittent hypoxic conditioning [IHC] as a potential therapeutic modality for surgical coronary artery bypass graft [CABG] patients. A brief history of IHC is reviewed along with a detailed review of known cellular mechanisms. Various review and primary studies on IHC are examined and show beneficial clinical outcomes for cardiovascular patients. This information is then used to develop protocol guidelines for incorporation of IHC into the clinical management of CABG patients. These guidelines address proper administration, clinical safety, and patient management. Among the findings of this review are that although more research is warranted to fully understand all the mechanisms and to optimize the administration of IHC, this therapy is likely a safe, non-invasive and non-pharmacological treatment that would be a useful aid to current cardiac management and rehabilitation.